Dr. Ibrahim Malami

Area of specialization:	Drug Discovery
Email:	ibrahim.malami@udusok.edu.ng
Phone:

List of Selected Publications

Selected publications: Untitled Document

1. A review of the medicinal uses and biological activities of Piliostigma thonningii (Schum). Milne-Redh Ibrahim Babangida Abubakar, Ibrahim Malami, Aliyu Muhamamd, Tijjani Salihu Shinkafi, Dayyabu Shehu, Patrick MaduabuchiAja.RPS Pharmacy and Pharmacology Reports. 2024; https://doi.org/10.1093/rpsppr/rqae004

2. Revolutionizing snakebite care with novel antivenoms: Breakthroughs and barriers. Uko SO, Malami I, Ibrahim KG, Lawal N, Bello MB, Abubakar MB, Imam MU. Heliyon. 2024; 30;10(3):e25531. DOI:10.1016/j.heliyon.2024.e25531. eCollection 2024 Feb 15.

3. Ibrahim Malami, Alhassan Alhassan, Adamu Adamu, Muhammad Bello, Aliyu Muhammad and Mustapha Imam. Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF Signalling Pathway. Curr Drug Targets. 2023; 24(11): 919 – 928. DOI: 10.2174/1389450124666230803153750

4. Katsayal, B.S., Forcados, G.E., Yusuf, A.P., Lawal, Y.A., Jibril, S.A., Nuraddeen, H., Ibrahim, M.M., Sadiq, I.Z., Abubakar, M.B., Malami, I., Abubakar, I.B., Muhammad, A., 2023. An insight into the mechanisms of action of selected bioactive compounds against epigenetic targets of prostate cancer: implications on histones modifications. In Silico Pharmacol 11.doi: 10.1007/s40203-023-00148-2.

5. Mutolib Olabayo Olatubosun, Murtala Bello Abubakar, Gaber El-Saber Batiha, Ibrahim Malami, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Athanasios Alexiou, Mustapha Umar Imam. LncRNA SNHG15: A potential therapeutic target in the treatment of colorectal cancer. Chem Biol Drug Des. 2023; 1–13.

6. Ibrahim Malami, Muhammad Muhammad Batako, Alhasan Muhammad Alhasan & Ibrahim Babangida Abubakar. Mitracarpus hirtus (L.) DC.: is a potential source for the exploitation of anticancer agents. Natural Product Research. 2023; DOI: 10.1080/14786419.2022.2140340

7. Aliyu Muhammad, Gilead Ebiegberi Forcados, Babangida Sanusi Katsayal, Rabiatu Suleiman Bako, Suleiman Aminu, Idris Zubairu Sadiq, Murtala Bello Abubakar, Abdurrahman Pharmacy Yusuf, Ibrahim Malami, Mohammed Faruk, Sani Ibrahim, Peter Abur Pase, Saad Ahmed, Ibrahim Babangida Abubakar, Murtala Abubakar & Clayton Yates. Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review. Epigenomics. 2022, 14(11):711-726.

8. A.M. Alhassan, A. Uba, C. Muhammad, H.L. Bako, I. Malami, Q.U. Ahmed, Y.I. Alkali. In-vitro cytotoxicity effects and bioactive constituents of chloroform extract of Vernonia glaberrima Welw. ex O. Hoffm (Asteraceae).Nigerian Journal of Basic and Applied Sciences. 2022; 30(1):77-80. DOI: 10.4314/njbas.v30i1.11

9. Bilyaminu Abubakar, Alhassan Muhammad Alhassan, Ibrahim Malami, Dawoud Usman, Yaaqub Abiodun Uthman, Kehinde Ahmad Adeshina, Mutolib Olabayo Olatubosun, and Mustapha Umar Imam. Evaluation of acute and sub-acute toxicity profile of 5-methylcoumarin-4β-glucoside in mice. Toxicol Rep. 2022; 9: 366–372.

10. Malami I, Bunza AM, Alhassan, AM, Muhammad A, Abubakar, IB, Yunusa A, Waziri PM, Etti IC. Dihydroartemisinin as a potential drug candidate for cancer therapy: a structural-based virtual screening for multitarget profiling. Journal of Biomolecular Structure and Dynamics. 2022; 40(3):1347-1362. doi: 10.1080/07391102.2020.1824811.

11. Alhassan M. Alhassan, Qamar Uddin Ahmed, Ibrahim Malami, Zainul Amiruddin Zakaria. Pseudocedrela kotschyi: a review of ethnomedicinal uses, pharmacology and Phytochemistry. Pharmaceutical Biology. 2021; 59(1): 955-963 DOI:10.1080/13880209.2021.1950776

12. Yaaqub Abiodun Uthman, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Ibrahim Malami, Mustapha Umar Imam, Naeem Qusty, Nat´alia Cruz-Martins, Gaber El-Saber Batiha, Murtala Bello Abubakar. MALAT1: A promising therapeutic target for the treatment of metastatic colorectal cancer. Biochemical Pharmacology. 2021; 190:114657. DOI: 10.1016/j.bcp.2021.114657

13. A.M Alhassan and I. Malami. In silico screening of sesquiterpene lactones as aldose reductase inhibitors. Nigerian Journal of Basic and Applied Science, 2020; 28(2): 64-69. DOI: 10.4314/njbas.v28i2.8

14. Muhammad A, Katsayal BS, Forcados GE, Malami I, Abubakar IB, Kandi AI, Idris AM, Yusuf S, Musa SM, Monday N, Umar ZS. In silico predictions on the possible mechanism of action of selected bioactive compounds against breast cancer. In Silico Pharmacol. 2020; 8(1):4. https://doi.org/10.1007/s40203-020-00057-8

15. Malami I, Jagaba, NM, Abubakar, IB, Muhammad, A, Alhassan, AM, Maitama, P., Zakiyya, I., Yahaya, Y., Emmanuel, H., Nefy, S. Heliyon Integration of medicinal plants into the traditional system of medicine for the7treatment of cancer in Sokoto State , Nigeria. Heliyon. 2020; 6(9): e04830. doi.org/10.1016/j.heliyon.2020.e04830

16. Abubakar IB, Ukwuani-Kwaja AN, Olayiwola FS, Malami I, Muhammad A, Ahmed SJ, Nurudeen OO, Falana MB. An inventory of medicinal plants used for treatment of cancer in Kwaraand Lagos state, Nigeria. European Journal of Integrative Medicine. 2020; 34: 101062.https://doi.org/10.1016/j.eujim.2020.101062

17. Malami I, Alhassan AM, Muhammad A, Abubakar IB. Expression of Wild-Type p53 by Curcumin, Alpinetin and Flavokawain B in Colorectal Cancer cells Expressing R273H Mutant p53. Nigerian Journal of Basic and Applied Science, 2019; 27(2): 88-94. DOI: 10.4314/njbas.v27i2.12

18. Malami I, Abdul AB. Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death: A molecular crosstalk between the enzyme and cellular apoptosis induction. Biomed Pharmacother. 2019; 109:1506-1510. DOI: 10.1016/j.biopha.2018.10.200

19. Muhammad A, Mada SB, Malami I, Forcados GF, Erukainure OL, Sani H, Abubakar IB. Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods. Biomedicine & Pharmacotherapy. 2018; 107: 571–582

20. Abubakar IB, Malami I, Yahaya Y, Manga SS. A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance. J Ethnopharmacol. 2018; 224:45-62

21. Malami I, Muhammad A, AbubakarIB, Etti IC, Waziri PM, Abubakar RM, Mshelia HE. 5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer. Nat Prod Res. 2018; 32(24):2964-67 doi: 10.1080/14786419.2017.1392954.

22. Muhammad A, Ibrahim MA, Erukainure OL, Malami I, Adamu A. Spices with Breast Cancer Chemopreventive and Therapeutic Potentials: A Functional Foods Based-Review. Anticancer Agents Med Chem. 2018; 18:182-194 doi: 10.2174/1871520617666170912121422

23. Malami I, Muhammad A, Etti IC, Waziri PM, Alhassan MA. An In silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53. EXCLI Journal. 2017; 16:1276-1287

24. Etti CI, Abdullah R, Kadir A, Hashim NM, Yeap SK, Imam MU, Ramli F,Malami I , Lam LK, Etti U,Waziri P, Rahman M. The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells. PLoSONE. 2017; 12(8):e0182357. https://doi.org/10.1371

. Etti CI, Abdullah R, Abdul Kadir A, Hashim NM, Yeap SK, Ramli F, , Lam LK, Malami I, Waziri P. Artonin E induces p53 independent G1 cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and livin suppression in MCF-7 cells. Drug Design, Development and Therapy. 2017; 11, 865-879

26. Malami I, Abdul AB, Abdullah R, Kassim K, Rosli R, Yeap SK, Waziri P, Etti IC, Bello MB. Crude extracts, flavokawain B and alpinetin compounds from the rhizome of Alpinia mutica induce cell death via UCK2 enzyme inhibition and in turn reduce 18S rRNA biosynthesis in HT-29 cells. PLoSONE. 2017; 12(1): e0170233. doi:10.1371/journal.pone.0170233

27. Waziri PM, Abdullah R, Yeap SK, Omar AR, Abdul AB, Kassim NK, Malami I, Karunakaran T, Imam MU. Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. J. Ethnopharmacol. 2016; 194: 549 – 558

28. Waziri PM, Abdullah R, Yeap SK, Omar AR, Kassim NK, Malami I, How CW, Etti IC, Abu ML. Clausenidin induces caspase-dependentapoptosis in colon cancer. BMC Complement Altern Med. 2016; 16: 256; doi: 10.1186/s12906-016-1247-1

29. Etti, I; Abdullah, R; Hashim NM; Kadir, A; Abdul, AB; Etti, C; Malami, I; Waziri, P; How, CW. Artonin E and Structural Analogs from ArtocarpusSpecies Abrogates Estrogen Receptor Signaling in Breast Cancer. Molecules. 2016, 21, 839; doi:10.3390/molecules21070839

30. Malami, I; Abdul, AB; Abdullah, R; Bt Kassim, NK; Waziri, P; Etti, IC. In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica. Molecules. 2016; 21, 417; doi: 10.3390/molecules21040417.

SELECTED CONFERENCES:

Untitled Document

1. Ibrahim Malami, Alhasan Muhammad Alhasan, Muhammad Bashir Bello, Aliyu Muhammad, Ibrahim Babangida Abubakar, Mustapha Umar Imam. Anti-metastasis effects of Flavokawain B inHepG2 hepatocellular carcinoma. A paper presented at the 12th NYA International Conference and General Assembly, 15th – 18th November, 2022, National Centre for Energy Research and Development, Nsukka

2. Ibrahim Malami, Alhassan Muhammad Alhassan, Mustapha Umar Imamand Bilyaminu Abubakar. 5-methylcoumarin-4β-glucoside reduces CEA, TAG-72 and TPA levels in AOM/DSS induced colitis associated cancer in mice. A paper presented at the 12th NYA International Conference and General Assembly, 15th – 18th November, 2022, National Centre for Energy Research and Development, Nsukka

3. Alhassan M. Alhassan, Ahmad Uba, Ibrahim Malami. Synthesis and In-vitro Anticancer Investigation of 7-chloro-4-geranylaminoquinoline. A paper presented at the 20th NAPA Annual National Scientific Conference, 15th – 19th August, 2022, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife

4. Malami, I and Alhassan, M.A. Investigating the possible mechanism of dihydroartemisinin action on the binding mode of human protein kinases as potential anticancer therapy. A paper presented at the38th NSBMB Scientific Conference & General Assembly Meeting, 6th – 10th June, 2021, University Auditorium, UDUS, Sokoto

5. I. Malamia, A.M. Alhasan, I.B. Abubakar, and A. Muhammad. AMP-activated Protein Kinase: A Tool for Cancer Research. A poster presented at the11th NYA International Conference and General Assembly, 23rd – 26th August, 2021, Abuja.

6. Malami Ibrahim, Alhassan Muhammad Alhassan, Aliyu Muhammad, Ibrahim Babangida Abubakar. Accessing the potential of antimalarial dihydroartemisinin to key hormonal signals critical for the growth of breast cancer. A paper presented at the 37th NSBMB Conference, 4th – 8th Nov, 2019, Umaru Musa Yar'Adua University, Katsina.

7. Dr. Ibrahim Malami. Targeting uridine-cytidine kinase 2 for cancer therapy: Paving the way for advanced treatment strategies. A scholarly paper presented at the 9th Nigerian Young Academy Conference and General Assembly, 26-28th Aug, 2019, Ahmadu Bello University, Zaria.

8. Ibrahim Malami. Uridine-cytidine kinase 2, a potential chemotherapeutic target for cancer therapy: The role of natural products in targeting UCK2 enzyme activity. A poster presented at the PSE-YSM, 2nd – 5th July, 2018, The Redmonds Building, Liverpool John Moores University Liverpool, United Kingdom